This injection procedure is performed to relieve low back and radiating leg pain. Steroid medication can reduce the swelling and inflammation caused by spinal conditions.

Epidural Steroid Injections

An epidural steroid injection (ESI) is a combination of a corticosteroid with a local anesthetic pain relief medicine. Corticosteroids are strong anti-inflammatory medicines used to relieve pain. The local anesthetic medicine helps give you immediate pain relief. Corticosteroid medicines take longer to have an effect. Within the spinal canal, an ESI is injected into the space around the spinal cord and nerve roots (epidural space). The injection does not go into the subacrachnoid space (thecal sac) that contains the spinal cord and nerve roots. ESIs sometimes are used to treat pain and inflammation from pressure on the spinal cord. ESI is usually not tried unless symptoms caused by lumbar spinal stenosis have not responded to other nonsurgical treatment. Imaging tests, such as magnetic resonance imaging (MRI) or computed tomography (CT) scans, are usually done before you are given the injection. These tests are used to identify the exact location where nerve roots are being squeezed. During the injection, an X-ray machine (fluoroscope) is often used to guide placement of the needle.
An epidural steroid injection (ESI) may be tried when before surgery, or other nonsurgical treatments have failed to relieve severe leg pain from lumbar spinal stenosis. The corticosteroids in an ESI can help provide relief from leg pain by reducing swelling and inflammation. Local anesthetics help relieve pain but do not reduce inflammation. Local anesthetics can also help relieve pain quickly, before the corticosteroid has taken effect.
Lumbar spinal stenosis may cause pain that radiates from the lower spine to the hips or down a leg/foot. Epidural steroid injections (ESIs) are used for leg pain rather than back pain from lumbar spinal stenosis. Steroid injections can help relieve pain for a short time (2 to 3 months) in some people. Experts do not know how well injections work over longer periods of time.1Some people get enough pain relief that they can delay or no longer need surgery.

Epidural steroid injections (ESIs) should be used with caution. This treatment may only relieve symptoms for a short time, and the long-term effects are not well studied. Most experts recommend that no more than 3 – 4 ESIs be given in a 12-month period. Doctors usually wait at least 2 months between injections. And they do not usually give more than 3 or 4 injections into one area.

If side effects occur, they are usually minor and may include:

  • About 2 to 4 days of back pain and tenderness where the injection was given.
  • Feeling sick to your stomach and sometimes vomiting.
  • Dizziness.
  • Headache.

More serious side effects are very rare but can include bleeding, infection, nerve root injury, and meningitis.


People who have an increased risk for infections, such as those with diabetes or those with immunosuppresion may be at a higher risk for problems from ESIs. People with mental health disorders may also have a higher risk for problems from this treatment.


See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

Epidural steroid injections (ESIs) should not be given if there is any sign of infection. ESIs may only relieve symptoms for a short time. The long-term effects are not well studied. Talk with your doctor about the risks related to the number of ESIs you expect to get. If lumbar spinal stenosis is caused by a congenitally (from birth) small spinal column, rather than by osteoarthritis or another degenerative bone or joint condition, corticosteroid injections could also help with such as pain and numbness.

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